Chikungunya virus–induced autophagy delays caspase-dependent cell death

@inproceedings{Joubert2012ChikungunyaVA,
  title={Chikungunya virus–induced autophagy delays caspase-dependent cell death},
  author={Pierre-Emmanuel Joubert and Scott W. Werneke and Claire de la Calle and Florence Guivel-Benhassine and Alessandra Giodini and Lucie Peduto and Beth Levine and Olivier Schwartz and Deborah J Lenschow and Matthew L Albert},
  booktitle={The Journal of experimental medicine},
  year={2012}
}
Autophagy is an important survival pathway and can participate in the host response to infection. Studying Chikungunya virus (CHIKV), the causative agent of a major epidemic in India, Southeast Asia, and southern Europe, we reveal a novel mechanism by which autophagy limits cell death and mortality after infection. We use biochemical studies and single cell multispectral assays to demonstrate that direct infection triggers both apoptosis and autophagy. CHIKV-induced autophagy is mediated by the… CONTINUE READING
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