Chicoric acid supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of NF-κB.

@article{Liu2017ChicoricAS,
  title={Chicoric acid supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of NF-κB.},
  author={Qian Liu and Yuwei Chen and Chun Shen and Yating Xiao and Yutang Wang and Zhigang Liu and Xuebo Liu},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2017},
  volume={31 4},
  pages={1494-1507}
}
Chicoric acid (CA), a natural phenolic acid extracted from chicory and the echinacea (purple coneflower) plant (Echinacea purpurea), has been regarded as a nutraceutical that has powerful antioxidant and antiobesity activities. We investigated the inhibitory effects of CA on systemic inflammation-induced neuroinflammation, amyloidogenesis, and cognitive impairment. C57BL/6J mice were treated with 0.05% CA in the drinking water for 45 d. The mice were then treated by intraperitoneal injection of… CONTINUE READING
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