Chicken hemogen homolog is involved in the chicken-specific sex-determining mechanism.

@article{Nakata2013ChickenHH,
  title={Chicken hemogen homolog is involved in the chicken-specific sex-determining mechanism.},
  author={Tomohiro Nakata and Manabu Ishiguro and Nana Aduma and Hiroe Izumi and A. Kuroiwa},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 9},
  pages={
          3417-22
        }
}
Using a comprehensive transcriptome analysis, a Z chromosome-linked chicken homolog of hemogen (cHEMGN) was identified and shown to be specifically involved in testis differentiation in early chicken embryos. Hemogen [Hemgn in mice, EDAG (erythroid differentiation-associated gene protein) in humans] was recently characterized as a hematopoietic tissue-specific gene encoding a transcription factor that regulates the proliferation and differentiation of hematopoietic cells in mammals. In chicken… CONTINUE READING
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