Chicken TLR21 is an innate CpG DNA receptor distinct from mammalian TLR9.

@article{Keestra2010ChickenTI,
  title={Chicken TLR21 is an innate CpG DNA receptor distinct from mammalian TLR9.},
  author={A. Marijke Keestra and Marcel R. de Zoete and Lieneke I. Bouwman and Jos P M van Putten},
  journal={Journal of immunology},
  year={2010},
  volume={185 1},
  pages={460-7}
}
TLRs comprise a family of evolutionary conserved sensory receptors that respond to distinct classes of ligands. For one major evolutionary branch of TLRs, the ligands are still largely unknown. Here we report the cloning and function of one member of this group, chicken TLR21 (chTLR21). This TLR is absent in the human species but has homologs in fish and frog and displays similarity with mouse TLR13. Expression of chTLR21 in HEK293 cells resulted in activation of NF-kappaB in response to… CONTINUE READING
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