Chicken IgL variable region gene conversions display pseudogene donor preference and 5' to 3' polarity.

@article{Mccormack1990ChickenIV,
  title={Chicken IgL variable region gene conversions display pseudogene donor preference and 5' to 3' polarity.},
  author={W T Mccormack and Craig B Thompson},
  journal={Genes & development},
  year={1990},
  volume={4 4},
  pages={548-58}
}
Chicken immunoglobulin variable region diversity is generated during B-cell development in the bursa of Fabricius by intrachromosomal gene conversion, resulting in the replacement of sequence blocks within the unique rearranged VL1 and VH1 genes with homologous sequences derived from V region pseudogene segments (psi V). In this report, the nucleotide sequences of 217 gene conversion events in 52 random IgL clones were analyzed to characterize the molecular mechanism of gene conversion. The… CONTINUE READING