Chick embryo proliferation studies using EdU labeling.

  title={Chick embryo proliferation studies using EdU labeling.},
  author={Michelle Warren and Karolina Puskarczyk and Susan C Chapman},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  volume={238 4},
Cell proliferation studies are an important experimental tool. The most commonly used thymidine analogues, tritiated thymidine and bromodeoxyuridine (BrdU) label cells during S-phase. Both methods have significant drawbacks: low sensitivity in the case of tritiated thymidine and a denaturation step during BrdU detection that destroys most cellular epitopes, requiring careful optimization. The antibody against BrdU is also large and tissue penetration can be difficult. EdU (5'-ethynyl-2… CONTINUE READING
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