Chick Dach1 interacts with the Smad complex and Sin3a to control AER formation and limb development along the proximodistal axis.

@article{Kida2004ChickDI,
  title={Chick Dach1 interacts with the Smad complex and Sin3a to control AER formation and limb development along the proximodistal axis.},
  author={Yasuyuki S. Kida and Yukiko Maeda and T. Shiraishi and Takayuki Suzuki and Toshihiko Ogura},
  journal={Development},
  year={2004},
  volume={131 17},
  pages={4179-87}
}
Based on recent data, a new view is emerging that vertebrate Dachshund (Dach) proteins are components of Six1/6 transcription factor-dependent signaling cascades. Although Drosophila data strongly suggest a tight link between Dpp signaling and the Dachshund gene, a functional relationship between vertebrate Dach and BMP signaling remains undemonstrated. We report that chick Dach1 interacts with the Smad complex and the corepressor mouse Sin3a, thereby acting as a repressor of BMP-mediated… CONTINUE READING

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