Chibby, an antagonist of the Wnt/beta-catenin pathway, facilitates cardiomyocyte differentiation of murine embryonic stem cells.

@article{Singh2007ChibbyAA,
  title={Chibby, an antagonist of the Wnt/beta-catenin pathway, facilitates cardiomyocyte differentiation of murine embryonic stem cells.},
  author={Amar M. Singh and Feng-qian Li and Takashi Hamazaki and Hideko Kasahara and Ken-Ichi Takemaru and Naohiro Terada},
  journal={Circulation},
  year={2007},
  volume={115 5},
  pages={617-26}
}
BACKGROUND Embryonic stem cell (ESC)-derived cardiomyocytes are anticipated to serve as a useful source for future cell-based cardiovascular disease therapies. Research emphasis is currently focused on determining methods to direct the differentiation of ESCs to a large population of cardiomyocytes with high purity. To this aim, understanding the molecular mechanisms that control ESC-to-cardiomyocyte differentiation should play a critical role in the development of this methodology. The Wnt… CONTINUE READING

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