Chfr is linked to tumour metastasis through the downregulation of HDAC1

@article{Oh2009ChfrIL,
  title={Chfr is linked to tumour metastasis through the downregulation of HDAC1},
  author={Young Mi Oh and Young Eun Kwon and Joo Mi Kim and Sung Jun Bae and Bo Keun Lee and Soon Ji Yoo and Chin Ha Chung and Raymond J Deshaies and Jae Hong Seol},
  journal={Nature Cell Biology},
  year={2009},
  volume={11},
  pages={295-302}
}
Chfr is a ubiquitin ligase that functions in the mitotic checkpoint by delaying entry into metaphase in response to mitotic stress. It has been suggested that Chfr is a tumour suppressor as Chfr is frequently silenced in human cancers. To better understand how Chfr activity relates to cell-cycle progression and tumorigenesis, we sought to identify Chfr-interacting proteins using affinity purification combined with mass spectrometry. Histone deacetylase 1 (HDAC1), which represses transcription… CONTINUE READING
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