Chfr and RNF8 synergistically regulate ATM activation

  title={Chfr and RNF8 synergistically regulate ATM activation},
  author={Jiaxue Wu and Y Eugene Chen and Lin-Yu Lu and Yipin Wu and Michelle T. Paulsen and Mats Ljungman and David O. Ferguson and Xiaochun Yu},
  booktitle={Nature Structural &Molecular Biology},
Protein ubiquitination is a crucial component of the DNA damage response. To study the mechanism of the DNA damage–induced ubiquitination pathway, we analyzed the impact of the loss of two E3 ubiquitin ligases, RNF8 and Chfr. Notably, DNA damage–induced activation of ATM kinase is suppressed in cells deficient in both RNF8 and Chfr (double-knockout, or DKO), and DKO mice develop thymic lymphomas that are nearly diploid but harbor clonal chromosome translocations. Moreover, DKO mice and cells… CONTINUE READING
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Activation of ATM depends on chromatin interactions occurring before induction of DNA damage

  • YC Kim
  • Nature cell biology
  • 2009

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