Chemotherapy plus involved-field radiation in early-stage Hodgkin's disease.

@article{Ferm2007ChemotherapyPI,
  title={Chemotherapy plus involved-field radiation in early-stage Hodgkin's disease.},
  author={Christophe Ferm{\'e} and Houchingue Eghbali and Jacobus H. Meerwaldt and Chantal Rieux and Jacques Bosq and Françoise Berger and Th{\'e}odore Girinsky and Pauline Brice and Mars B van't Veer and Jan Walewski and Pierre Lederlin and Umberto Tirelli and Patrice Carde and Eric van den Neste and Emmanuel Gyan and Mathieu Monconduit and Marine Divin{\'e} and John M. M. Raemaekers and Gilles Salles and Evert M. Noordijk and G. J. M. Creemers and Jean Gabarre and Anton Hagenbeek and Oum{\'e}daly Reman and Michel Blanc and Jos{\'e} Juli{\'a}n Llaguno Thomas and Brigitte Vi{\'e} and Johanna C Kluin-Nelemans and F. Viseu and Joke W. Baars and Philip M. P. Poortmans and Pieternella J Lugtenburg and Christian Carri{\'e} and J{\'e}r{\^o}me Jaubert and M. Henry-Amar},
  journal={The New England journal of medicine},
  year={2007},
  volume={357 19},
  pages={
          1916-27
        }
}
BACKGROUND Treatment of early-stage Hodgkin's disease is usually tailored in line with prognostic factors that allow for reductions in the amount of chemotherapy and extent of radiotherapy required for a possible cure. METHODS From 1993 to 1999, we identified 1538 patients (age, 15 to 70 years) who had untreated stage I or II supradiaphragmatic Hodgkin's disease with favorable prognostic features (the H8-F trial) or unfavorable features (the H8-U trial). In the H8-F trial, we compared three… CONTINUE READING

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