Chemotherapy of MMR-deficient colorectal cancer

  title={Chemotherapy of MMR-deficient colorectal cancer},
  author={Nicol{\'a}s Devaud and Steven Gallinger},
  journal={Familial Cancer},
Colorectal cancer (CRC) continues to rank as the third most common cancer in Western society and the second leading cause of cancer death in North America. There are at least three distinct, and relatively discreet, molecular pathways associated with this disease: chromosomal instability (CIN), microsatellite instability (MSI) and the cytosine polyguanine island methylator phenotype. Defects in the DNA mismatch repair system (MMR) account for the MSI phenotype and genotype of about 15 % of CRC… CONTINUE READING
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