Chemotherapy induces the expression of cyclooxygenase-2 in non-small cell lung cancer.

@article{Altorki2005ChemotherapyIT,
  title={Chemotherapy induces the expression of cyclooxygenase-2 in non-small cell lung cancer.},
  author={Nasser Khaled Altorki and Jeffrey L. Port and Fan Zhang and Dragan Golijanin and Howard T. Thaler and Anna J. Duffield-Lillico and Kotha Subbaramaiah and Andrew J. Dannenberg},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2005},
  volume={11 11},
  pages={4191-7}
}
PURPOSE To determine the effect of taxane-based chemotherapy on intratumoral levels of cyclooxygenase-2 (COX-2) and prostaglandin E(2) (PGE(2)) in patients with non-small cell lung cancer (NSCLC). EXPERIMENTAL DESIGN Lung specimens obtained at the time of surgery were used to measure levels of COX-2 and PGE(2) in tumors and adjacent nontumorous tissues in three subsets of NSCLC patients who underwent: (A) surgical resection only (n = 16); (B) surgical resection after preoperative taxane-based… CONTINUE READING
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