Chemotherapy induces intratumoral expression of chemokines in cutaneous melanoma, favoring T-cell infiltration and tumor control.

@article{Hong2011ChemotherapyII,
  title={Chemotherapy induces intratumoral expression of chemokines in cutaneous melanoma, favoring T-cell infiltration and tumor control.},
  author={M. L. Hong and Anne-Laure Puaux and Caleb Huang and Laure Loumagne and Charlene Tow and Charles R Mackay and Masashi Kato and Armelle Pr{\'e}vost-Blondel and M Avril and Alessandra Nardin and J. -P. Abastado},
  journal={Cancer research},
  year={2011},
  volume={71 22},
  pages={6997-7009}
}
T-cell infiltration is known to impact tumor growth and is associated with cancer patient survival. However, the molecular cues that favor T-cell infiltration remain largely undefined. Here, using a genetically engineered mouse model of melanoma, we show that CXCR3 ligands and CCL5 synergize to attract effector T cells into cutaneous metastases, and their expression inhibits tumor growth. Treatment of tumor-bearing mice with chemotherapy induced intratumoral expression of these chemokines and… CONTINUE READING