Chemotherapy induces an increase in coenzyme Q10 levels in cancer cell lines.

@article{BreaCalvo2006ChemotherapyIA,
  title={Chemotherapy induces an increase in coenzyme Q10 levels in cancer cell lines.},
  author={Gloria Brea-Calvo and Angeles Rodr{\'i}guez-Hern{\'a}ndez and Daniel Jos{\'e} Moreno Fern{\'a}ndez-Ayala and Placido Navas and Jos{\'e} A S{\'a}nchez-Alc{\'a}zar},
  journal={Free radical biology & medicine},
  year={2006},
  volume={40 8},
  pages={
          1293-302
        }
}
Free radicals have been implicated in the action of many chemotherapeutic drugs. Here we tested the hypothesis that camptothecin and other chemotherapeutic drugs, such as etoposide, doxorubicin, and methotrexate, induce an increase in coenzyme Q(10) levels as part of the antioxidant defense against free radical production under these anticancer treatments in cancer cell lines. Chemotherapy treatment induced both free radical production and an increase in coenzyme Q(10) levels in all the cancer… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 32 CITATIONS