Chemotherapy-induced neutropenia: risks, consequences, and new directions for its management.

@article{Crawford2004ChemotherapyinducedNR,
  title={Chemotherapy-induced neutropenia: risks, consequences, and new directions for its management.},
  author={J. Crawford and David C Dale and Gary H. Lyman},
  journal={Cancer},
  year={2004},
  volume={100 2},
  pages={228-37}
}
Cytotoxic chemotherapy suppresses the hematopoietic system, impairing host protective mechanisms and limiting the doses of chemotherapy that can be tolerated. Neutropenia, the most serious hematologic toxicity, is associated with the risk of life-threatening infections as well as chemotherapy dose reductions and delays that may compromise treatment outcomes. The authors reviewed the recent literature to provide an update on research in chemotherapy-induced neutropenia and its complications and… CONTINUE READING
Highly Influential
This paper has highly influenced 12 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 233 extracted citations

Management of Infections in the Immunocompromised Host

Springer International Publishing • 2018
View 5 Excerpts
Highly Influenced

G-CSF control of neutrophils dynamics in the blood.

Bulletin of mathematical biology • 2007
View 1 Excerpt
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 63 references

Predictors for chemotherapy-related severe or febrile neutropenia: a review of the clinical literature

M Wilson-Royalty, G Lawless, C Palmer, R. Brown
J Oncol Pharm Pract • 2002
View 4 Excerpts
Highly Influenced

2002 guidelines for the use of antimicrobial agents in neutropenic patients with cancer.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America • 2002
View 5 Excerpts
Highly Influenced

Cost and mortality associated with febrile neutropenia in adult cancer patients [abstract 998

N Kuderer, LE Cosler, J Crawford, DC Dale, GH. Lyman
Proc Am Soc Clin Oncol • 2002
View 6 Excerpts
Highly Influenced

Prospective patient registry for the development of risk models of neutropenic complications including febrile neutropenia (FN) [abstract 5593

DC Dale, D Wolff, O Agboola, J Crawford, GH. Lyman
2002
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…