Chemotherapy-induced cell death in primary cerebellar granule neurons but not in astrocytes: in vitro paradigm of differential neurotoxicity.

@article{Wick2004ChemotherapyinducedCD,
  title={Chemotherapy-induced cell death in primary cerebellar granule neurons but not in astrocytes: in vitro paradigm of differential neurotoxicity.},
  author={Antje Wick and Wolfgang Wick and Johannes Hirrlinger and Ellen Gerhardt and Ralf Dringen and Johannes Dichgans and Michael Weller and J{\"o}rg Bernhard Schulz},
  journal={Journal of neurochemistry},
  year={2004},
  volume={91 5},
  pages={1067-74}
}
The nervous system is frequently the site of symptomatic toxicity of antineoplastic agents. However, there is limited information about the differential vulnerability of neurons, astrocytes and glioma cells. We have analyzed the effects of four chemotherapeutic drugs (lomustine, cisplatin, topotecan and vincristine) on primary cerebellar granule neurons and astrocytes derived from rats. All drugs led to cell death in cerebellar granule neurons in a concentration-dependent manner. Comparison of… CONTINUE READING

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