Chemotherapy in metastatic renal cell carcinoma today? A systematic review

@article{Buti2013ChemotherapyIM,
  title={Chemotherapy in metastatic renal cell carcinoma today? A systematic review},
  author={Sebastiano Buti and Melissa Bersanelli and Angelica Sikokis and Francesca Maines and Francesco Facchinetti and Emilio Bria and Andrea Ardizzoni and Giampaolo Tortora and Francesco Massari},
  journal={Anti-Cancer Drugs},
  year={2013},
  volume={24},
  pages={535–554}
}
The prognosis of patients affected by metastatic renal cell carcinoma (mRCC) has improved markedly with targeted therapies. Unfortunately, 20–25% of the patients are refractory to treatment at the first response assessment and most patients will acquire drug resistance during the treatment. Moreover, current data on the clinical activity of targeted agents in poor risk or non-clear-cell mRCC patients are inconclusive because of the absence of prospective trials. Therefore, there are still… 
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