Chemotherapy in locally advanced head and neck cancer: a critical reappraisal.

@article{Jassem1995ChemotherapyIL,
  title={Chemotherapy in locally advanced head and neck cancer: a critical reappraisal.},
  author={Jacek Jassem and Harry Bartelink},
  journal={Cancer treatment reviews},
  year={1995},
  volume={21 5},
  pages={
          447-62
        }
}
are detected in less than 10% of cases. Most of the patients with locally advanced tumours are managed with external beam irradiation with or without surgery. Despite the continued refinement of radiotherapy techniques, local tumour control remains a significant problem, with a recurrence rate of up to 60% (3,4). The majority of deaths from this malignancy are attributable to progressive locoregional disease. Many patients suffer significant morbidity both from the therapy and from cancer… CONTINUE READING
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