Chemotherapy for the treatment of malignant peripheral nerve sheath tumors in neurofibromatosis 1: a 10-year institutional review

@inproceedings{Zehou2013ChemotherapyFT,
  title={Chemotherapy for the treatment of malignant peripheral nerve sheath tumors in neurofibromatosis 1: a 10-year institutional review},
  author={Ouidad Zehou and Elizabeth Fabre and Laurent Zelek and E Sbidian and N Ortonne and E. Anandha Banu and Pierre Wolkenstein and Laurence L Valeyrie-Allanore},
  booktitle={Orphanet journal of rare diseases},
  year={2013}
}
BACKGROUND Neurofibromatosis 1 (NF1) is the most common autosomal dominant disorder, with an incidence of 1 in 2,500-3,300 live births. NF1 is associated with significant morbidity and mortality because of complications, especially malignant peripheral nerve sheath tumors (MPNSTs), which mainly develop during adulthood. We evaluated our experience with management of NF1 with MPNSTs by standard chemotherapy with anthracycline and/or ifosfamide in terms of time to treatment failure and overall… CONTINUE READING