Chemotherapy and dasatinib induce long-term hematologic and molecular remission in systemic mastocytosis with acute myeloid leukemia with KIT D816V.

@article{Ustun2009ChemotherapyAD,
  title={Chemotherapy and dasatinib induce long-term hematologic and molecular remission in systemic mastocytosis with acute myeloid leukemia with KIT D816V.},
  author={Celalettin Ustun and Christopher L . Corless and Natasha Savage and Warren Fiskus and Elizabeth Manaloor and Michael C Heinrich and Grant C Lewis and P. Sethu Ramalingam and Ilana Kepten and Anand Prasad Jillella and Kapil Bhalla},
  journal={Leukemia research},
  year={2009},
  volume={33 5},
  pages={735-41}
}
Dasatinib has been reported to potently inhibit juxtamembrane domain mutant KIT(D816V) autophosphorylation and KIT-dependent activation of down stream signaling important for cell growth and survival of neoplastic cells. Additionally, dasatinib induced apoptosis in mast cell and leukemia cell lines expressing KIT(D816V). Here, we present the first case report of long-term hematologic and molecular remission achieved with combined treatment with chemotherapy and dasatinib in a patient with… CONTINUE READING
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