Chemotherapy and cardiotoxicity in older breast cancer patients: a population-based study.

  title={Chemotherapy and cardiotoxicity in older breast cancer patients: a population-based study.},
  author={John J Doyle and Alfred I. Neugut and Judith S. Jacobson and Victor R. Grann and Dawn L. Hershman},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  volume={23 34},
PURPOSE Adjuvant chemotherapy, especially with anthracyclines, is known to cause acute and chronic cardiotoxicity in breast cancer patients. We studied the cardiac effects of chemotherapy in a population-based sample of breast cancer patients aged > or = 65 years with long-term follow-up. PATIENTS AND METHODS In the Surveillance, Epidemiology, and End Results (SEER)-Medicare database, we analyzed treatments and outcomes among women > or = 65 years of age who were diagnosed with stage I to III… CONTINUE READING


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