Chemotherapy agent cisplatin induces 48-h Fos expression in the brain of a vomiting species, the house musk shrew (Suncus murinus).

@article{Jonghe2009ChemotherapyAC,
  title={Chemotherapy agent cisplatin induces 48-h Fos expression in the brain of a vomiting species, the house musk shrew (Suncus murinus).},
  author={Bart C De Jonghe and Charles C Horn},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2009},
  volume={296 4},
  pages={
          R902-11
        }
}
Cancer chemotherapy drugs, such as cisplatin, potently produce nausea and vomiting. Acute effects of these treatments are partly controlled by antiemetic drugs, but the delayed effects (>24 h), especially nausea, are more difficult to treat. It is unknown what brain pathways produce this delayed sickness. Our prior data show that brain Fos expression is increased for at least 48 h after cisplatin treatment in the rat, a nonvomiting species. Here, we extend these observations by using house musk… CONTINUE READING

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