Chemotherapy accelerates the development of acquired immune responses to Schistosoma haematobium infection.

@article{Mutapi1998ChemotherapyAT,
  title={Chemotherapy accelerates the development of acquired immune responses to Schistosoma haematobium infection.},
  author={Francisca Mutapi and Patricia Doris Ndhlovu and Paul Hagan and James Spicer and Takafira Mduluza and Charles M. R. Turner and Stephen K. Chandiwana and Mark E. J. Woolhouse},
  journal={The Journal of infectious diseases},
  year={1998},
  volume={178 1},
  pages={289-93}
}
Treatment of 41 Schistosoma haematobium-infected children, 5-16 years old, with the drug praziquantel induced a switch from a predominantly IgA-specific antibody response to a predominantly IgG1 response within 12 weeks. A cross-sectional survey suggests that the same switch occurs naturally, but over several years, as children age (n = 251). The switch may be driven by alterations in cytokine levels in response to the release of antigens by dead or damaged parasites. Adults are more resistant… CONTINUE READING

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