Chemotherapy: friend or foe to cancer vaccines?

  title={Chemotherapy: friend or foe to cancer vaccines?},
  author={Leisha A. Emens and J. P. Machiels and Richard T Reilly and Elizabeth M. Jaffee},
  journal={Current opinion in molecular therapeutics},
  volume={3 1},
Cancer vaccines are on the threshold of taking their place alongside the more traditional cancer treatment modalities of surgery, radiation therapy and chemotherapy. The toxicology and immunopharmacology of therapeutic cancer vaccines, particularly those that secrete granulocyte macrophage colony stimulating factor (GM-CSF), are currently under active clinical investigation. Interestingly, drugs traditionally used for tumor cytoreduction can have both positive and negative effects on host… CONTINUE READING