Chemotherapeutic drugs change actin skeleton organization and the expression of β-thymosins in human breast cancer cells

@article{Otto2002ChemotherapeuticDC,
  title={Chemotherapeutic drugs change actin skeleton organization and the expression of β-thymosins in human breast cancer cells},
  author={Albrecht Otto and Christine M{\"u}ller and T G Huff and Ewald Hannappel},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2002},
  volume={128},
  pages={247-256}
}
Purpose: Elevated expression of the β-thymosin isotypes Tβ4, Tβ10, and T15 appears to be involved in the manifestation of a malignant phenotype of human tumor cells, including those of mammary carcinomas. This has evoked an interest in these peptides as diagnostic/prognostic tumor markers. If increased levels of β-thymosins correspond to tumor malignancy, the question arises whether tumor growth inhibition induced by chemotherapeutic drugs would reduce their expression. Methods: Two human… CONTINUE READING

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