Chemotherapeutic approaches to schistosomes: current knowledge and outlook

  title={Chemotherapeutic approaches to schistosomes: current knowledge and outlook},
  author={Achim Harder},
  journal={Parasitology Research},
  • A. Harder
  • Published 1 May 2002
  • Biology, Medicine
  • Parasitology Research
Abstract. The chemotherapy of schistosomiasis has improved greatly in the last few decades. There are three drugs available: metrifonate (active against Schistosoma haematobium), oxamniquine (active against Schistosoma mansoni) as narrow spectrum drugs and praziquantel, which is effective against all important adult schistosome species and their immature stages, as the drug of choice. 
New insight into praziquantel against various developmental stages of schistosomes
The present review article reviews the effects and mechanism of action of praziquantel against schistosomes briefly and suggests the research on this oddity phenomenon.
PZQ Therapy: How Close are we in the Development of Effective Alternative Anti-schistosomal Drugs?
Due to the high prevalence of this disease and the steady increase in the infection rates, praziquantel (PZQ) remains the only effective drug against this acute disease although it has no effect on the juvenile schistosome parasite.
Current and prospective chemotherapy options for schistosomiasis
This review discusses potential mechanisms of PZQ action and how molecular changes in schistosome parasites may lead to resistance, and the identification of critical molecular targets inschistosomes leading to the development of new drugs is urgently needed for the future treatment ofSchistosomiasis.
Schistosomiasis Mansoni: Novel Chemotherapy Using a Cysteine Protease Inhibitor
A significant reduction in parasite burden and pathology by this vinyl sulfone cysteine protease inhibitor validates schistosome cysteined proteases as drug targets and offers the potential of a new direction for chemotherapy of humanSchistosomiasis.
Schistosomiasis—a century searching for chemotherapeutic drugs
Several recently described gene products that are promising target candidates for existing or new drugs for schistosomiasis therapy are put forward.
Chemotherapeutic approaches to trematodes (except schistosomes) and cestodes: current level of knowledge and outlook
  • A. Harder
  • Biology, Chemistry
    Parasitology Research
  • 2001
Disintegration of membrane integrity (Boray 1994; Harder 2000): formation of free radicals leads to peroxidation of macromolecules – lipids, proteins, nucleic acids.
Protein kinases as potential targets for novel anti-schistosomal strategies.
Promising results have been obtained indicating the potential of PKs as privileged targets for new concepts in fighting schistosomes, and clear evidence for the molecular armamentarium of schistOSomes with multidrug transporters was found.
Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis
Use of PZQ will increase in the foreseeable future, whether given alone or coadministered with other anthelminthics in integrated control programmes, as well as inhibitors of a schistosome-specific bifunctional enzyme, thioredoxin-glutathione reductase.
The redox biology of schistosome parasites and applications for drug development.
The redox biology of schistosomes is discussed and their potential use as drug targets is reviewed and it is hoped that compounds targeting parasite antioxidant responses will become clinically relevant drugs in the near future.


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