Chemotherapeutic agents that induce mitochondrial apoptosis.

  title={Chemotherapeutic agents that induce mitochondrial apoptosis.},
  author={Tadashi Asakura and Kiyoshi Ohkawa},
  journal={Current cancer drug targets},
  volume={4 7},
In cancer chemotherapy, it is necessary to design an agent that suppresses or inhibits the targets that influence cell growth and apoptosis. We focus on the apoptotic pathway via mitochondria in this article. In this pathway, c-Jun N-terminal kinase (JNK), one of the stress activated protein kinases, is predominantly activated by apoptotic stimuli. JNK activity is inhibited by the binding of glutathione S-transferase P1-1 (GST P1-1) through protein-protein interactions. It has been noted that… CONTINUE READING
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