Chemotherapeutic agents induce the expression and activity of their clearing enzyme CYP3A4 by activating p53.

@article{Goldstein2013ChemotherapeuticAI,
  title={Chemotherapeutic agents induce the expression and activity of their clearing enzyme CYP3A4 by activating p53.},
  author={Ido Goldstein and Noa Rivlin and Or-yam Shoshana and Osnat Ezra and Shalom Madar and Naomi Goldfinger and Varda Rotter},
  journal={Carcinogenesis},
  year={2013},
  volume={34 1},
  pages={190-8}
}
Cytochrome P450 (P450) enzymes are abundantly expressed in the human liver where they hydroxylate organic substrates. In a microarray screen performed in human liver cells, we found a group of eleven P450 genes whose expression was induced by p53 (CYP3A4, CYP3A43, CYP3A5, CYP3A7, CYP4F2, CYP4F3, CYP4F11, CYP4F12, CYP19A1, CYP21A2 and CYP24A1). The mode of regulation of four representative genes (CYP3A4, CYP3A7, CYP4F2 and CYP4F3) was further characterized. The genes were induced in a p53… CONTINUE READING

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