Chemotherapeutic agents do not interact with neurotransmitter receptors


The interactions of cisplatin, 5-fluorouracil, doxorubicin, mitomycin, carmustine (BCNU), cyclophosphamide, methotrexate and thio-TEPA were assessed at three neurotransmitter receptor binding sites. Each drug was inactive at concentrations as high as 10-4 M in displacing the specific binding of 3H-spiperone to dopamine D2, 3H-pyrilamine to histamine H1, and… (More)
DOI: 10.1007/BF00254564


Cite this paper

@article{Peroutka1987ChemotherapeuticAD, title={Chemotherapeutic agents do not interact with neurotransmitter receptors}, author={Stephen J. Peroutka}, journal={Cancer Chemotherapy and Pharmacology}, year={1987}, volume={19}, pages={131-132} }