Chemotherapeutic agents augment TRAIL-induced apoptosis in human hepatocellular carcinoma cell lines.

@article{Yamanaka2000ChemotherapeuticAA,
  title={Chemotherapeutic agents augment TRAIL-induced apoptosis in human hepatocellular carcinoma cell lines.},
  author={Takenari Yamanaka and Katsuya Shiraki and Kazushi Sugimoto and Tatsuo Ito and Katsuhiko Fujikawa and Mitsuhiro Ito and Koujiro Takase and Masaru Moriyama and Takeshi Nakano and Akihiko Suzuki},
  journal={Hepatology},
  year={2000},
  volume={32 3},
  pages={482-90}
}
TNF-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis in various transformed cell lines but not in almost-normal tissues. It is regulated by 2 death receptors, TRAIL receptor 1 (TRAIL-R1) and TRAIL-R2, and 2 decoy receptors, TRAIL-R3 and TRAIL-R4. We investigated the expression of TRAIL-R- and TRAIL-induced apoptosis in human hepatocellular carcinomas (HCCs). TRAIL-R1, -R2, and -R4 were expressed in 6 HCC cell lines examined, but TRAIL-R3 was expressed in only 2 of the 6… CONTINUE READING

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