Chemotherapeutic CNS prophylaxis and neuropsychologic change in children with acute lymphoblastic leukemia: a prospective study.

@article{Espy2001ChemotherapeuticCP,
  title={Chemotherapeutic CNS prophylaxis and neuropsychologic change in children with acute lymphoblastic leukemia: a prospective study.},
  author={Kimberly Andrews Espy and Ida M Ki Moore and Prof. Dr. med. Dr. h.c. M. Kaufmann and Joel H. Kramer and Katherine K. Matthay and John J. Hutter},
  journal={Journal of pediatric psychology},
  year={2001},
  volume={26 1},
  pages={1-9}
}
OBJECTIVE To determine whether prophylactic CNS chemotherapy for childhood acute lymphoblastic leukemia is associated with declines in neuropsychological abilities. METHODS Growth curve analysis was used to examine neuropsychological outcome and treatment-related change in children (N = 30) who were treated at two childhood cancer centers. A comprehensive test battery was administered at baseline (8 months), 2, 3, and 4 years postdiagnosis (age at diagnosis M = 5.90 years, SD = 4.2C… CONTINUE READING