Chemotactic responses of IL-4-, IL-10-, and IFN-gamma-producing CD4+ T cells depend on tissue origin and microbial stimulus.

@article{Debes2006ChemotacticRO,
  title={Chemotactic responses of IL-4-, IL-10-, and IFN-gamma-producing CD4+ T cells depend on tissue origin and microbial stimulus.},
  author={Gudrun F Debes and Martin E. Dahl and Azita Josefine Mahiny and Kerstin Bonhagen and Daniel J Campbell and Kerstin Siegmund and Klaus Joseph Erb and David B Lewis and Thomas Kamradt and Alf Hamann},
  journal={Journal of immunology},
  year={2006},
  volume={176 1},
  pages={557-66}
}
Th1- and Th2-polarized immune responses are crucial in the defense against pathogens but can also promote autoimmunity and allergy. The chemokine receptors CXCR3 and CCR4 have been implicated in differential trafficking of IFN-gamma- and IL-4-producing T cells, respectively, but also in tissue and inflammation-specific homing independent of cytokine responses. Here, we tested whether CD4+ T cells isolated from murine tissues under homeostatic or inflammatory conditions exhibit restricted… CONTINUE READING

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