Chemotactic effect of ciliary neurotrophic factor on macrophages in retinal ganglion cell survival and axonal regeneration.

@article{Cen2007ChemotacticEO,
  title={Chemotactic effect of ciliary neurotrophic factor on macrophages in retinal ganglion cell survival and axonal regeneration.},
  author={Ling-Ping Cen and Jian-min Luo and Cheng-wu Zhang and You-Ming Fan and Yue Song and Kwok-fai So and Nico Van Rooijen and Chi Pui Pang and Dennis Shun Chiu Lam and Qi Qi Cui},
  journal={Investigative ophthalmology & visual science},
  year={2007},
  volume={48 9},
  pages={4257-66}
}
PURPOSE To examine whether ciliary neurotrophic factor (CNTF) has a chemotactic effect on macrophages and whether macrophages are involved in CNTF-induced retinal ganglion cell (RGC) survival and axonal regeneration after optic nerve (ON) injury. METHODS Adult Fischer 344 rats received an autologous peripheral nerve graft onto transected ON for injured axons to grow. CNTF was applied intravitreally. When needed, clodronate liposomes were applied intravitreally or intravenously to deplete… CONTINUE READING
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