Chemosensitization to cisplatin by inhibitors of the Fanconi anemia/BRCA pathway.

@article{Chirnomas2006ChemosensitizationTC,
  title={Chemosensitization to cisplatin by inhibitors of the Fanconi anemia/BRCA pathway.},
  author={Deborah Chirnomas and Toshiyasu Taniguchi and Michelle de la Vega and Ami P Vaidya and Maria Vasserman and Anne-Renee Hartman and Richard Kennedy and Rosemary Foster and Jennifer Luppens Mahoney and Michael V. Seiden and Alan D D'Andrea},
  journal={Molecular cancer therapeutics},
  year={2006},
  volume={5 4},
  pages={
          952-61
        }
}
Cisplatin resistance occurs, at least in part, through the function of the Fanconi anemia (FA)/BRCA pathway, a DNA-damage response pathway required for repair of cisplatin cross-links. In the current study, we designed a cell-based screening strategy to identify small-molecule inhibitors of the FA/BRCA pathway with the hypothesis that such molecules could restore sensitivity to platinum agents. We identified four inhibitors, including three protein kinase inhibitors (wortmannin, H-9, and… CONTINUE READING

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