Chemosensitization of hormone-refractory prostate cancer cells by curcumin to TRAIL-induced apoptosis.

@article{Deeb2005ChemosensitizationOH,
  title={Chemosensitization of hormone-refractory prostate cancer cells by curcumin to TRAIL-induced apoptosis.},
  author={Dorrah Deeb and Hao Jiang and Xiaohua Gao and George W. Divine and Scott A. Dulchavsky and Subhash C. Gautam},
  journal={Journal of experimental therapeutics & oncology},
  year={2005},
  volume={5 2},
  pages={81-91}
}
Failure to undergo apoptosis has been implicated in the resistance of tumor cells to anticancer therapies. Promotion of apoptosis in tumor cells could potentially increase the efficacy of conventional treatment regimens and improve prognosis. Prostate cancer cells are generally resistant to induction of apoptosis by anticancer agents and death ligands. We investigated the sensitization of prostate cancer cell lines by curcumin (diferuloyl-methane) to TNF-related apoptosis inducing ligand (TRAIL… CONTINUE READING
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