Chemosensitization of doxorubicin in multidrug-resistant cells by unimolecular micelles via increased cellular accumulation and apoptosis.

@article{Wang2016ChemosensitizationOD,
  title={Chemosensitization of doxorubicin in multidrug-resistant cells by unimolecular micelles via increased cellular accumulation and apoptosis.},
  author={Meng Yu Wang and Min Han and Ying Li and Yi Jin and Jianqing Gao},
  journal={The Journal of pharmacy and pharmacology},
  year={2016},
  volume={68 3},
  pages={
          333-41
        }
}
OBJECTIVES Unimolecular micelles were prepared by modification of polyamidoamine (PAMAM) dendrimers using Pluronic F127 (PF127), which is expected to reverse multidrug resistance (MDR). And the reversal mechanisms have been studied. METHODS Characterization of the products was carried on. MTT assay was used to evaluate the cytotoxicity of the DOX-loaded conjugates. Cellular uptake study was measured by confocal laser scanning microscope and flow cytometry. Apoptosis assay was identified by… CONTINUE READING
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