Chemosensitization of androgen-independent prostate cancer with neutral endopeptidase.


PURPOSE We investigated whether neutral endopeptidase (NEP) could augment chemosensitivity to anticancer drugs by promoting protein kinase C (PKC)delta-mediated mitochondrial apoptosis in prostate cancer (PC) cells. EXPERIMENTAL DESIGN Human PC cell lines LNCaP and PC-3, and a normal prostate epithelial cell line (PrEC) were used. The protein expression… (More)


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