Chemosensitization of B-cell lymphomas by methylseleninic acid involves nuclear factor-kappaB inhibition and the rapid generation of other selenium species.

@article{Jliger2007ChemosensitizationOB,
  title={Chemosensitization of B-cell lymphomas by methylseleninic acid involves nuclear factor-kappaB inhibition and the rapid generation of other selenium species.},
  author={Simone J{\"u}liger and Heidi Goenaga-Infante and T. Andrew Lister and Jude Fitzgibbon and Simon P. Joel},
  journal={Cancer research},
  year={2007},
  volume={67 22},
  pages={10984-92}
}
Although recent reports suggest that selenium can modulate the activity of cytotoxic drugs, the mechanism underlying this activity remains unclear. This has been investigated using a panel of human B-cell lymphoma cell lines. The cytotoxic effects of chemotherapeutic agents (e.g., doxorubicin, etoposide, 4-hydroperoxycyclophosphamide, melphalan, and 1-beta-d-arabinofuranosylcytosine) were increased by up to 2.5-fold when combined with minimally toxic concentrations (EC(5-10)) of the organic… CONTINUE READING
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