Chemosensitization by antisense oligonucleotides targeting MDM2.

  title={Chemosensitization by antisense oligonucleotides targeting MDM2.},
  author={Roberto Bianco and Fortunato Ciardiello and Giampaolo Tortora},
  journal={Current cancer drug targets},
  volume={5 1},
The MDM2 oncogene is overexpressed in many human cancers, including sarcomas, certain hematologic malignancies, and breast, colon and prostate cancers. The p53-MDM2 interaction pathway has been suggested as a novel target for cancer therapy. To that end, several strategies have been explored, including the use of small polypeptides targeted to the MDM2-p53 binding domain, anti-MDM2 antisense oligonucleotides, and natural agents. Different generations of anti-human-MDM2 oligonucleotides have… CONTINUE READING


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