Chemoselective attachment of small molecule effector functionality to human adenoviruses facilitates gene delivery to cancer cells.

@article{Banerjee2010ChemoselectiveAO,
  title={Chemoselective attachment of small molecule effector functionality to human adenoviruses facilitates gene delivery to cancer cells.},
  author={Partha Sarathi Banerjee and Philomena Ostapchuk and Patrick Hearing and Isaac Sheridan Carrico},
  journal={Journal of the American Chemical Society},
  year={2010},
  volume={132 39},
  pages={13615-7}
}
We demonstrate here a novel two-step "click" labeling process in which adenoviral particles are first metabolically labeled during production with unnatural azido sugars. Subsequent chemoselective modification allows access to viruses decorated with a broad array of effector functionality. Adenoviruses modified with folate, a known cancer-targeting motif, demonstrated a marked increase in gene delivery to a murine cancer cell line. 

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