Chemoradiotherapy of newly diagnosed glioblastoma with intensified temozolomide.

@article{Weiler2010ChemoradiotherapyON,
  title={Chemoradiotherapy of newly diagnosed glioblastoma with intensified temozolomide.},
  author={Markus Weiler and Christian Hartmann and Dorothee Wiewrodt and Ulrich Herrlinger and Thierry Gorlia and Oliver B{\"a}hr and Richard Meyermann and Michael Bamberg and Marcos Tatagiba and Andreas von Deimling and Michael Weller and Wolfgang Wick},
  journal={International journal of radiation oncology, biology, physics},
  year={2010},
  volume={77 3},
  pages={670-6}
}
PURPOSE To evaluate the toxicity and efficacy of chemoradiotherapy with temozolomide (TMZ) administered in an intensified 1-week on/1-week off schedule plus indomethacin in patients with newly diagnosed glioblastoma. PATIENTS AND METHODS A total of 41 adult patients (median Karnofsky performance status, 90%; median age, 56 years) were treated with preirradiation TMZ at 150 mg/m(2) (1 week on/1 week off), involved-field radiotherapy combined with concomitant low-dose TMZ (50 mg/m(2… CONTINUE READING

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