Chemoprotective effects of carnosine against genotoxicity induced by cyclophosphamide in mice bone marrow cells

  title={Chemoprotective effects of carnosine against genotoxicity induced by cyclophosphamide in mice bone marrow cells},
  author={Farshad Naghshvar and Shahrzad Mohseni Abianeh and Saeb Ahmadashrafi and Seyed Jalal Hosseinimehr},
  journal={Cell Biochemistry and Function},
The protective effects of carnosine as a natural dipeptide were investigated in mouse bone marrow cells against genotoxicity induced by cyclophosphamide. Mice were injected with solutions of carnosine at three different doses (10, 50 and 100 mg kg–1 bw) for five consecutive days. On the fifth day of treatment, mice were injected cyclophosphamide and killed after 24 h. The frequency of micronuclei in polychromatic erythrocytes and the ratio of polychromatic erythrocyte/polychromatic erythrocyte… 

Effects of carnosine on cyclophosphamide-induced hematopoietic suppression in mice.

The data suggest that carnosine holds a potential in clinical application to minimize the side effects induced by chemotherapeutic agents such as cyclophosphamide and thus will substantially improve the overall anti-tumor effects of the standard chemotherapies.

The Possible Protective Role of Lemon Fruit Extract Against Cytogenetic Effects Induced by Cyclophosphamide in Male Albino Mice

LFE could be concomitantly as a supplement to protect people undergoing chemotherapy against DNA damage in bone marrow cells was evaluated using micronucleus assay of male mice treated with cyclophosphamide.

Carnosine mitigates apoptosis and protects testicular seminiferous tubules from gamma‐radiation‐induced injury in mice

Results indicate that carnosine prevents testicular dysfunction induced by gamma‐irradiation via an anti‐apoptotic effect; this restoration of proper testicular function ultimately leads to the recovery of spermatogenesis.

AgNPs Argovit™ Modulates Cyclophosphamide-Induced Genotoxicity on Peripheral Blood Erythrocytes In Vivo

This work evaluates the genotoxic and cytotoxic potential of the Argovit™ formulation on BALB/c mice using the micronucleus in a peripheral blood erythrocytes model and reports the first time that the exceptional chemoprotective capacity produced by a non-cytotoxic silver nanoparticle formulation against CP genot toxic damage has been reported.

Investigation of role magnetized water used in supplementary feeding for honeybees to modulate the genotoxic side effects induced by cyclophosphamide in mice bone marrow cells

Honey HW can be used as an adjuvant with chemotherapeutic agents for minimizing the genotoxic side effects of the anticancer drug CP and confirmed the protective efficacy of HW group and/or HF group as compared with HS group, against CP-toxicity.


Cisplatin administration produced oxidative stress by increased generation of reactive oxygen species which consequently resulted in genotoxicity in male Sprague Dawley rats.

The protective effect of lemon fruit extract on histopathological changes induced in small intestines and pancreas of male mice by cyclophosphamide

The results support the protective effect of lemon fruit extract against CP-induced intestinal and pancreatic injury.

Psoralen suppresses the phosphorylation of amyloid precursor protein (APP) to inhibit myelosuppression.

Evaluation of lemon fruit extract as an antioxidant agent against histopathological changes induced by cyclophosphamide in the testes of albino mice

  • S. Quita
  • Chemistry, Medicine
    Electronic physician
  • 2016
Lemon fruit extract in conjunction with drug treatment protects the testicular tissue against CP-induced testicular injury in mice.

The biological role of carnosine and its possible applications in medicine.

  • S. BudzeńJ. Rymaszewska
  • Biology
    Advances in clinical and experimental medicine : official organ Wroclaw Medical University
  • 2013
Carnosine is already used by athletes to achieve better results, due to its buffering feature, which contributes to the maintenance of the acid-base balance in the muscles, in addition to improving both amateur and professional athletes' results.



Chemoprotective effects of hesperidin against genotoxicity induced by cyclophosphamide in mice bone marrow cells

Hesperidin, may with antioxidative activity, reduced the oxidative stress and genotoxicity induced by cyclophosphamide in mouse bone marrow cells and completely normalized PCE/ (PCE+NCE) ratio.

Chemoprotective Effects of Zataria multiflora Against Genotoxicity Induced by Cyclophosphamide in Mice Bone Marrow Cells

ZM with antioxidative activity reduced the oxidative stress and genotoxicity induced by CP in mouse bone marrow cells and completely normalized the PCE/ (PCE + NCE) ratio.

Citrus extract modulates genotoxicity induced by cyclophosphamide in mice bone marrow cells

It appeared that citrus extract, particularly flavonoids constituents with antioxidative activity, may return the GSH level to normal in stress conditions and reduces genotoxicity induced by cyclophosphamide in bone marrow cells.

Radioprotective effects of hesperidin against gamma irradiation in mouse bone marrow cells.

It is demonstrated that hesperidin has powerful protective effects on the radiation-induced DNA damage and on the decline in cell proliferation in mouse bone marrow.

Radioprotective Effects of Citrus Extract Against γ-Irradiation in Mouse Bone Marrow Cells

Fruits and vegetables contain flavonoids to be useful as protective effects under such stress conditions as irradiation, and citrus extract was contained in citrus extract, probably to show protective activity, and reduced the clastogenic effect of radiation on mice bone marrow.

The radioprotective effect of Zataria multiflora against genotoxicity induced by γ irradiation in human blood lymphocytes.

Zataria extract exhibited concentration-dependent radical-scavenging activity on 1,1-diphenyl-2-picryl hydrazyl free radicals, which has an important application for the protection of human lymphocyte from the genetic damage and side-effects induced by γ irradiation in personnel exposed to radiation.

Protective effect of carnosine against cisplatin-induced nephrotoxicity in mice.

Anti-oxidative and anti-genotoxic effects of carnosine on human lymphocyte culture

The results suggest that carnosine could provide anti-oxidative and anti-genotoxic protection for the oxidative and genotoxic agents that cause many diseases including cancer and neurodegenerative disease.