Chemoprotection by D-methionine against cisplatin-induced side-effects: insight from in vitro studies using human plasma.

Abstract

Animal studies have shown that the nephrotoxicity and ototoxicity of the anti-cancer drug cisplatin (CP) can be ameliorated by the co-administration with D-methionine. The molecular mechanisms of this activity, however, are not well understood. Since CP is intravenously administered, the underlying chemistry may involve the interaction of CP-derived Pt… (More)
DOI: 10.1039/c3mt00238a

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