Chemoprophylactic Antimicrobial Activity of Gallium Maltolate against Intracellular Rhodococcus equi

  title={Chemoprophylactic Antimicrobial Activity of Gallium Maltolate against Intracellular Rhodococcus equi},
  author={Ronald J. Martens and Nicole A. Miller and Noah D Cohen and Jessica R. Harrington and Lawrence R. Bernstein}
The objective of this study was to assess the ability of prophylactically administered gallium maltolate (GaM) to inhibit growth or kill Rhodococcus equi within murine macrophage-like (J774A.1) cells. Cells were treated with three different doses of GaM or a single dose of maltol (equivalent to the concentration present in the highest dose of GaM studied); they were then infected with virulent R. equi and incubated. Quantitative cultures of R. equi from lysed macrophages were obtained at 0, 24… CONTINUE READING

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Pharmacokinetics of enteral gallium maltolate in neonatal foals

  • RJ Martens, K Mealey, ND Cohen, JR Harrington, MK Chaffin, RJ Taylor
  • Am J Vet Res (in press). RJ Martens et al Vol 27…
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Gallium therapy: a novel metal-based antimicrobial strategy for potential control of Rhodococcus equi foal pneumonia

  • RJ Martens, JR Harrington, +4 authors LR. Bernstein
  • Proc Am Assoc Equine Pract 2006;52:219–221
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