Chemopreventive promise of targeting the Nrf2 pathway.

  title={Chemopreventive promise of targeting the Nrf2 pathway.},
  author={Melinda Sue Yates and Thomas Wells Kensler},
  journal={Drug news & perspectives},
  volume={20 2},
The Kelch ECH associating protein 1-nuclear factor-E2-related factor 2-antioxidant response element (Keap 1-Nrf2-ARE) signaling pathway regulates several protective mechanisms including expression of conjugating and antioxidative genes, antiinflammatory responses, the molecular chaperone/stress response system and the ubiquitin/proteasome system. The Nrf2-mediated response alters susceptibility to carcinogenesis, acute chemical toxicity, oxidative stress, asthma, acute inflammation, septic… CONTINUE READING


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