Chemopreventive efficacies of aspirin and sulindac against lung tumorigenesis in A/J mice.

@article{Duperron1997ChemopreventiveEO,
  title={Chemopreventive efficacies of aspirin and sulindac against lung tumorigenesis in A/J mice.},
  author={C Duperron and Andr{\'e} Castonguay},
  journal={Carcinogenesis},
  year={1997},
  volume={18 5},
  pages={1001-6}
}
Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely prescribed drugs. In this study, we demonstrated the efficacy of aspirin to inhibit lung tumorigenesis in A/J mice. Lung tumors (9.9 tumors/mouse) were induced by the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), administered in drinking water between week 0 and week +7. Groups of mice were fed sulindac (123 mg/kg diet), acetylsalicylic acid (ASA; 294 mg/kg), non-buffered Aspirin (294… CONTINUE READING
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