Chemopreventive efficacies of aspirin and sulindac against lung tumorigenesis in A/J mice.

  title={Chemopreventive efficacies of aspirin and sulindac against lung tumorigenesis in A/J mice.},
  author={C Duperron and Andr{\'e} Castonguay},
  volume={18 5},
Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely prescribed drugs. In this study, we demonstrated the efficacy of aspirin to inhibit lung tumorigenesis in A/J mice. Lung tumors (9.9 tumors/mouse) were induced by the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), administered in drinking water between week 0 and week +7. Groups of mice were fed sulindac (123 mg/kg diet), acetylsalicylic acid (ASA; 294 mg/kg), non-buffered Aspirin (294… CONTINUE READING
55 Citations
35 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 55 extracted citations


Publications referenced by this paper.
Showing 1-10 of 35 references

The relevance of tobacco-specific antipyretics, anti-inflammatory agents: the salicylates. In Goodman,L.S. nitrosamines to human cancer

  • A. Goodman Gilman, L. S. Goodman, A. Gilman
  • Analgesic-25.Hecht,S.S. and Hoffmann,D
  • 1990
Highly Influential
3 Excerpts

high levels of cDNAderived CYP 2 D 6

  • T. J. Smith, G. D. Stoner, C. S. Yang
  • Pharmacogenetics
  • 1995

Nonsteroidal Carcinogenesis

  • M. A. Trujillo, H. S. Garewald, R. E. Sampliner
  • 1994

, expressed in hepatoma cells

  • B. W. Penman, J. Reece, +9 authors C. L. Crespi
  • Cancer Res .
  • 1993

Characterization of a human cell line expressing

  • C. G. Van Arman, E. A. Risley, G. W. Nuss, H. B. Hucker, D. E. Duggan, C. L. Crespi
  • 1993

Inhibitory effects of nonsteroidal antiinflammatory drugs ( NSAIDs ) on the metabolism of 4( methylnitrosamino )1( 3pyridyl )1butanone ( NNK ) in mouse lung explants

  • L. Bouchard
  • Drug Metab . Disp .
  • 1993

Similar Papers

Loading similar papers…