Chemopreventive effects of Frondanol A5, a Cucumaria frondosa extract, against rat colon carcinogenesis and inhibition of human colon cancer cell growth.

@article{Janakiram2010ChemopreventiveEO,
  title={Chemopreventive effects of Frondanol A5, a Cucumaria frondosa extract, against rat colon carcinogenesis and inhibition of human colon cancer cell growth.},
  author={Naveena B. Janakiram and Altaf Mohammed and Yuting Zhang and C W Choi and Carl Woodward and Peter Collin and Vernon E. Steele and Chinthalapally V Rao},
  journal={Cancer prevention research},
  year={2010},
  volume={3 1},
  pages={82-91}
}
Sea cucumber extracts have been widely used to treat individuals with inflammatory conditions in East Asia. The present study has been designed to test potential colon cancer-preventive properties of Frondanol A5, a glycolipid extract from the sea cucumber, Cucumaria frondosa, using in vivo and in vitro models of colon cancer. Chemopreventive efficacy of Frondanol A5 was evaluated on azoxymethane-induced rat colon carcinogenesis using colonic aberrant crypt foci (ACF) as efficacy marker. At 7… CONTINUE READING
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1 Excerpt

Frondanol A 5 : A novel nutrapreventive and therapeutic agent derived from sea cucumber showing promising antiproliferative , anti - inflammatory and anti - angiogenic activities

  • P Collin, TE Adrain, A Roginsky
  • Abstract A 80 , ChemopreventionExperimental…
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