Chemoprevention of lung cancer by isothiocyanates and their conjugates in A/J mouse.

@article{Chung2001ChemopreventionOL,
  title={Chemoprevention of lung cancer by isothiocyanates and their conjugates in A/J mouse.},
  author={Eric A. L. Chung},
  journal={Experimental lung research},
  year={2001},
  volume={27 3},
  pages={
          319-30
        }
}
The discovery of dietary-related compounds with potential to inhibit lung cancer may present promising and practical approaches for reducing the risk of lung cancer caused by smoking. To this end, we have conducted mechanism-based bioassays in A/J mice over the years to screen compounds, particularly isothiocyanates (ITCs) in the crucifer family, and studied their modes of action against lung tumorigenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a nicotine-derived lung… CONTINUE READING

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