Chemoprevention of colon cancer by calcium, vitamin D and folate: molecular mechanisms

Abstract

Recent findings have indicated that dietary calcium, vitamin D and folate can modulate and inhibit colon carcinogenesis. Supporting evidence has been obtained from a wide variety of preclinical experimental studies, epidemiological findings and a few human clinical trials. Important molecular events and cellular actions of these micronutrients that contribute to their tumour-modulating effects are discussed. They include a complex series of signalling events that affect the structural and functional organization of colon cells.

DOI: 10.1038/nrc1144
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@article{Lamprecht2003ChemopreventionOC, title={Chemoprevention of colon cancer by calcium, vitamin D and folate: molecular mechanisms}, author={Sergio A. Lamprecht and Martin Lipkin}, journal={Nature Reviews Cancer}, year={2003}, volume={3}, pages={601-614} }